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Sunday, October 1, 2017

Influenza (Swine Flu)

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Observation of World Heart Day 2017 at PPT Hospital

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World Heart Day-2017

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Friday, September 29, 2017

World Heart Day observed in Paradip Port Hospital

video

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Saturday, January 14, 2017

Treatment of Type II Diabetes Mellitus (T2DM) with Metformin in a nutshell



Metformin is a Biuagnide. It was derived from the herb Galega officinalis (French lilac, also known as Goat’s Rue or Italian Fitch) 


and has been used as a traditional botanical (tea infusion) for over 3,000 years to relieve polyuria (frequent urination) and halitosis (sweet odor on the breath), both are now well known symptoms of diabetes.
 

  • It was approved for the treatment of hyperglycemia in Britain since the late 1950’s, Canada in the 1970’s and U.S. in 1995.

  • Metformin is the most widely prescribed anti-diabetes drug (over 120 million prescriptions filled yearly worldwide).

Mechanism of action
      Lowers both basal and postprandial plasma glucose. 
      It decreases hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis. Enhances secretion of GLP-1 and peptide YY, which in turn affect systemic mechanisms including reducing hepatic glucose production through glucagon suppression and enhanced glucose-dependent insulin secretion
      Delays intestinal absorption of glucose

    Enhances insulin sensitivity by increasing peripheral glucose uptake and utilization.
      Some other unclear pathway
What is the Waiting Time to Show Effect?
      Usually, dose is gradually increased from 500 mg-1000 mg-1500 mg-1700 mg-2000 mg-2550 mg
      Gradual Increment lessens GI side effects
      May take days together to show its’ full effect, if prescribed in this manner.
      Mostly, effect is seen after 1500 mg/day dose is reached.
Whether Extended Release or Plain tablet?
  •   Extended Release is better tolerated-Maximum dose 2000 mg/day. Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment. Swallow the extended-release tablet whole with a full glass of water. Do not crush, break, or chew it.  
  •  Plain tablet-maximum dose-2550 Mg
What are the types of technology of manufacture?
      Dissolution/erosion controlled release
      Diffusion controlled release
      Osmotic controlled release
When to be taken?
If in single dose
  • Morning!
                Or
  • Evening!
If, taken in the evening, it works better by suppressing hepatic neoglucogenesis that occurs towards dawn.
What is passing in Stool? What is Ghost Pill?
Some patient see passing out of tablet in stool. They apprehend, the medicine might not be working. Why is passing out in stool?
It is the technology for delayed release of the ingredients and un digested portion comes out in feces.
Important Side Effects!
      Vomiting (Gastritis) and Diarrhea!
      Headache
      Lactic Acidosis
      Sometimes B12 deficiency: vitamin B-12 concentrations of ≤ 150 pmol/l; Dietary calcium or Vit. B12 supplementation
The mechanism of vitamin B12 deficiency with metformin is undoubtedly due to malabsorption of vitamin B12 at its absorption site in the terminal ileum. Absorption of the vitamin B12-intrinsic factor complex is calcium dependent and metformin interferes with its’ effect on calcium-dependent membrane action in the terminal ileum.
In support of this hypothesis is evidence that dietary calcium supplementation reverses metformin-induced vitamin B12 malabsorption.
Can it be prescribed to Patients of Impaired Kidney Function?
What is Impaired Kidney Function
      Generally, 90-120 ml/minute/1.73 m2 of eGFR is taken as normal value.
       Levels below 60 mL/min/1.73 m2 for 3 or more months are a sign of chronic kidney disease.
      A GFR lower than 15 mL/min/1.73 m2 is a sign of kidney failure and requires immediate medical attention.
      Hence, in addition to the level of serum creatinine (creatinine levels reach 1.4 mg per dL {120 μmol per L) in women or 1.5 mg per dL (130 μmol per L) in men}.
Labeling Change Recommendation-FDA: FDA concluded, from the review of studies published in the medical literature, that metformin can be used safely in patients with mild impairment in kidney function and in some patients with moderate impairment in kidney function.
      eGFR below 30 mL/minute/1.73 m2: Metformin is contraindicated
      eGFR between 30-45 mL/minute/1.73 m2: Starting metformin is not recommended.
      Patients taking metformin whose eGFR later falls below 45 mL/minute/1.73 m2: assess the benefits and risks of continuing treatment. Discontinue metformin, if the patient’s eGFR later falls below 30 mL/minute/1.73 m2.

Precautions:
  • Before starting metformin, obtain the patient’s eGFR (glomerular filtration rate estimating equation).
  • It is recommended to have the eGFR estimated in patients of T2DM before starting of Metformin or metformin in combination; also periodically measure, while on the medication.
      Obtain an eGFR at least annually in all patients taking metformin. In patients at increased risk for the development of renal impairment such as the elderly, renal function should be assessed more frequently.
      Discontinue metformin at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30 and 60 mL/minute/1.73 m2; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Re-evaluate eGFR 48 hours after the imaging procedure; restart metformin, if renal function is stable.
Other Uses!
      PCOS (Polycystic Ovary Syndrome)
      Cancer (Breast, Colon, Lung, Pancreas and Prostate)!
It is believed that systemic effect of metformin manifested by the reduction of circulating level of insulin and insulin-like growth factor 1 (IGF-1) might be associated with anticancer action.
Old is Gold
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Saturday, December 24, 2016

After supper walk a mile to burn more Fat!

The old saying, “after lunch rest a while, after supper walk a mile’ may hold good; a recent research, published in the Science Daily, suggests. 
The use of lipids/fats and glucose in muscle depends on the circadian rhythm and may have a role in metabolic disorders like obesity and diabetes. 
The research team performed a number of functional genomics studies that established the link between HDAC3 (Histone Deacetylase3) and the circadian clock. 
In normal mice, when the mouse is awake, the clock in the muscle anticipates a feeding cycle and uses HDAC3 to turn off many metabolic genes. This leads the muscles to use more carbohydrate. When the animal is about to go to sleep and anticipates a fasting cycle, the clock removes HDAC3. This leads the muscles to use more lipid. 
Although these studies were done in mice, the researchers speculate that human muscles most likely will follow the same cycle. The study opens the possibility of promoting body fat burning by increasing exercise activity during the periods in which muscles use lipid, which is at night for people. 
The master clock in the SCN (Suprachiasmatic Nucleus in Hypothalamus) drives circadian rhythms of behavior including the sleep-wake cycle and feeding patterns.
Overview of biological circadian clock in huma...
Overview of biological circadian clock in humans. Biological clock affects the daily rhythm of many physiological processes. This diagram depicts the circadian patterns typical of someone who rises early in morning, eats lunch around noon, and sleeps at night (10 p.m.). Although circadian rhythms tend to be synchronized with cycles of light and dark, other factors - such as ambient temperature, meal times, stress and exercise - can influence the timing as well. (Photo credit: Wikipedia)
Circadian rhythms are generated at the cellular level by a self-sustained molecular clock. Exposure to alternating cycles of light and darkness synchronizes the SCN clock, thereby aligning behavior with the solar cycle.
The SCN regulates rhythmic synthesis of endocrine factors, including the release of glucocorticoids, which can potentially synchronize peripheral clocks. Through its effects on feeding cycles, the SCN can also coordinate the timing of peripheral cellular oscillators.
In general, the primary function of clock control of processes is to prepare the cell/tissue for a predictable event before its onset; through regulation of metabolism, circadian clocks likely allow anticipation of daily fluctuations in energy demand and/or nutrient availability (e.g. increased physical activity during the awake phase).
Common behavioral/environmental risk factors for cardiometabolic diseases (e.g. food intake, physical activity, lighting, etc.) are known to influence circadian clocks in a tissue-specific manner, leading to the suggestion that circadian misalignment contributes toward obesity, diabetes mellitus, and cardiovascular disease. 
Losing body fat would be easier by exercising lightly and fasting at night. "It's not a bad idea to take a walk after dinner."

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